Objectives To study the extent of blinding in randomised clinical trials of psychological interventions and the interpretative considerations if randomised clinical trials are not blinded. Design ...

2 Department of Public Health, University of Oxford, Oxford, UK If you wish to reuse any or all of this article please use the link below which will take you to the ...

In a formerly widespread approach to medical decision making, physicians made a diagnosis, considered the management alternatives, and informed patients what would be done to help them. Decision ...

Correspondence to Sir Iain Chalmers, James Lind Initiative, Summertown Pavilion, Middle Way, Oxford OX2 7LG, UK; ichalmers{at}jameslind.net We are surrounded by maelstroms of claims about the effects ...

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Objectives Systematic reviews and meta-analyses are the foundation of modern evidence-based medicine and their use is becoming more prolific than randomised trials. However, systematic reviews are ...

Evidence-informed decision-making (EIDM) refers to the systematic and transparent process of identifying, appraising and mobilising the best available evidence to inform the development of safe and ...

Objectives Cancer overdiagnosis is a polarizing topic, with much disagreement on its drivers, magnitude, and implications. Overdiagnosis is also complex, as various factors interact to influence said ...

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Objective To estimate associations between trivalent influenza vaccination and COVID-19 mortality as well as severe clinical outcomes among hospitalised patients. Design Retrospective observational ...

Correspondence to: Johns Hopkins University School of Medicine, 5300 Alpha Commons Drive #429, Baltimore, MD 21224 USA; prosenb9{at}jhmi.edu If you wish to reuse any ...

Introduction There is growing interest in applying shared decision making approaches to support informed consent, a vital but challenging aspect of conducting clinical research. We systematically ...