lupus.bmj

Lupus Science & Medicine®

is a global, peer-reviewed, open access lupus journal from LFA, publishing papers on all aspects of lupus and related diseases.
Lupus Science & Medicine

Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE

Introduction Patients with SLE have an increased risk of infections and infection-related mortality, which may be associated ...
Lupus Science & Medicine

International development of a lupus-specific instrument to assess cognitive symptoms in patients with SLE: Lupus Brain Fog Severity Scale (LBFSS) study

Introduction Cognitive symptoms such as ‘brain fog’ are frequent and disabling in patients with SLE. We aimed to develop and ...
Lupus Science & Medicine

Upadacitinib enhances platelet procoagulant responses in a subset of healthy individuals and patients with SLE: a pilot study

Background Janus kinase inhibitors (JAKis) are emerging therapies for SLE, but concerns regarding thromboembolic risk persist ...
Lupus Science & Medicine

Qualitative interview study in patients with SLE to assess patient perception of fatigue and skin-related symptoms

Objective SLE is a chronic autoimmune disorder with a range of symptoms. While these are broadly reported in the literature, ...
lupus.bmj

Demographic and clinical characteristics of patients with systemic lupus erythematosus across five registries: the LupusNet federated data network

Objective This study describes baseline demographics, clinical characteristics and treatments of patients diagnosed with systemic lupus erythematosus (SLE) at the time of registration in the ...
lupus.bmj

Unsupervised clustering of clinical and laboratory features of systemic lupus erythematosus: insights from a multicentre cohort

Objective This study explored the relationship between clinical phenotypes and immuno-molecular features of systemic lupus erythematosus (SLE) using unsupervised machine learning and multi-omics ...
lupus.bmj

Risk factor of osteoporosis in systemic lupus erythematosus patients: a cross-sectional study in a tertiary hospital in Indonesia

Introduction Osteoporosis and fragility fracture are more frequently found in systemic lupus erythematosus (SLE) patients than in normal population. This study aims to determine the risk factors in ...
lupus.bmj

Mechanistic study of compound Muniziqi granule on lupus nephritis in MRL/lpr mice: insights from transcriptomics and experimental validation

Background Lupus nephritis (LN) is a severe and prevalent complication of SLE. Compound Muniziqi granule (CMG), a traditional remedy, is commonly used to treat immune system-related disorders. However ...
lupus.bmj

Age-related patterns of organ damage impact on health-related quality of life in SLE

Objective To characterise the age-related impact of organ damage patterns on health-related quality of life (HRQoL) in patients with SLE and to identify specific damage patterns affecting physical and ...
lupus.bmj

Amelioration of renal injury by Qihuang Jianpi Zishen Granules in lupus mice is correlated with AMPK/ULK1-dependent modulation of macrophage polarisation

Objective To investigate the effects of Qihuang Jianpi Zishen Granules (QJZG) on renal injury in SLE mice, focusing on macrophage M1/M2 polarisation mediated by the AMPK/ULK1 signalling pathway.
lupus.bmj

13 Managing skin manifestations in SLE

Fumaric acid esters in cutaneous lupus erythematosus Fumaric acid esters (FAEs), established immunomodulatory agents in the treatment of psoriasis and multiple sclerosis, have been investigated for ...