Latest research | eLife
WEBAug 20, 2024 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
How to measure and evaluate binding affinities | eLife
WEBAug 6, 2020 · Quantitative measurements of biomolecule associations are central to biological understanding and are needed to build and test predictive and mechanistic models. Given the advances in high-throughput technologies and the projected increase in the availability of binding data, we found it especially timely to evaluate the current standards for ...
For Authors: A simpler way to submit to eLife
WEBMar 11, 2019 · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
Cancer-associated fibroblasts and their influence on tumor ... - eLife
WEBDec 28, 2020 · Additionally, fibroblasts can exert a strong immunomodulatory influence, regulating the infiltration and phenotype of immune cells within the TME and influencing their spatial localization and functionality intra-tumorally. In this review, we focus on the intersection of fibroblast-derived factors and tumor immunity and discuss the role of ...
Science Forum: SARS-CoV-2 (COVID-19) by the numbers - eLife
WEBMar 31, 2020 · Abstract. The COVID-19 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this article we provide a one-stop, curated graphical source for the key numbers (based mostly on the …
Meta-Research: Tracking the popularity and outcomes of all ... - eLife
WEBApr 24, 2019 · Using preprint downloads as a metric for readership, we find that bioRxiv’s usage among readers is also increasing rapidly ().The total download count in October 2018 (1,140,296) was an 82% increase over October 2017, which itself was a 115% increase over October 2016 ().BioRxiv preprints were downloaded almost 9.3 million times in the first 11 months of 2018, and in October and November ...
The Natural History of Model Organisms: The secret lives of
WEBJun 4, 2015 · D. melanogaster, described by Meigen in 1830, appears to have originated in sub-Saharan Africa (Lachaise et al., 1988).The first out-of-Africa habitat expansion of D. melanogaster is thought to have occurred between 10,000 and 15,000 years ago, when it moved to Europe and Asia (David and Capy, 1988).North America and Australia were colonized more recently (David and Capy, 1988).
An optimized CRISPR/Cas9 approach for precise genome editing …
WEBMar 10, 2021 · Abstract. The efficient knock-in of large DNA fragments to label endogenous proteins remains especially challenging in non-dividing cells such as neurons. We developed T argeted K nock- I n with T wo (TKIT) guides as a novel CRISPR/Cas9 based approach for efficient, and precise, genomic knock …
Reviewed Preprints - eLife
WEB6 days ago · eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that encourages and recognises the most responsible behaviours in science. eLife Sciences Publications, Ltd is a limited liability non-profit non-stock corporation incorporated in the State of Delaware ...
The right time for senescence - eLife
WEBNov 10, 2021 · Cellular senescence is a highly complex and programmed cellular state with diverse and, at times, conflicting physiological and pathological roles across the lifespan of an organism. Initially considered a cell culture artifact, senescence evolved from an age-related circumstance to an intricate cellular defense mechanism in response to stress ...