David Sinclair Recommended Supplements List (2025)

I recently shared about berberine, a natural compound that supports fat metabolism and improves insulin sensitivity in a way similar to metformin. Since then, I’ve been asked whether eating barberries can provide a natural source of berberine. Barberries do contain berberine, usually around 5–7 percent, but the amount varies and you would need to eat a lot to reach an effective dosage. That’s why a high-quality berberine supplement is usually more reliable. Barberries and other nutrient-dense fr

Berberine has become a popular supplement for supporting healthy blood sugar. I was recently asked whether it should be taken before high-carb meals. Here's my perspective: Berberine activates the same metabolic pathway as metformin, called AMPK. While that’s promising, the most effective and reliable way to activate this pathway is through regular movement and exercise. Berberine can be a helpful tool, yet it works best as part of a thoughtful daily routine (supplementing and movement), not as