Metformin vs Berberine. Can one be substituted for the other? Berberine, a natural compound found in plants, has a good safety profile and causes less GI distress compared to metformin. It improves insulin sensitivity and may even improve cholesterol levels. But swapping depends on your willingness to adjust doses and monitor closely for optimal results. The decision – as with every health decision – is ultimately yours. Speak with your doctor to see if metformin or berberine is right for you. |